100% Natural. No animal products. GMO Free.
Purified Cord Blood MSC Exosomes in saline.
Cellgenic Exosomes is a purified xeno-free, chemically defined, cell-free cord blood MSC derived exosome re-suspended in 0.9% normal saline.Contains over 5 billion purified MSC exosomes per vial.
Since few transplanted cells persist in vivo, the beneficial effects of cell therapy may lie in the secreted factors being the active component of this treatment. A key part of paracrine secretion is Exosomes, which are membrane vesicles that are stored intracellularly in endosomal compartments and are secreted when these structures fuse with the cell plasma membrane.
Exosomes contain protein, DNA, and RNA, thus making them an attractive vector of paracrine signals delivered by stem cells.
Exosomes may also be "loaded" with predetermined proteins and nucleic acid to achieve a desired effect (1).
Exosomes can be stored as an "off-the-shelf" product having the potential for circumventing many of the limitations of\viable cells for therapeutic applications in regenerative medicine.
In vitro, exosomes from pre-adipocytes stimulate cell proliferation in a wound healing model.
In vivo, adipose-graft derived exosomes have been shown to be a promising tool for skin repair and remodeling (2)
Sterile-filtered without radiation, No cryoprotectant or dilutants ever used
Endotoxin and USP <71> testing on all lots. Non Expanded/Non Cultured
100% pure liquid allogeneic secretion. Maximum bioavailability. Non-nucleated cell
Quality Compliance & Donor Screening
Cellgenic Exosomes is procured and processed in the United States according to standards and regulations established by the American Association of Tissue Banks (AATB), the United States Food & Drug Administration (FDA). All local donors. Donor ethics and non-reactive FDA approved serological screening includes:
Donor Consent Priorto Collections
HCV (Hepatitis C Antibody)
HBsAG (Hepatitis B Surface Antigen)
HIV 1/11-Ab (HIV Nucleic Acid Test)
HBcAb (Hepatitis B core Antibody)
HCV NAt (HCV Nucleic Acid Test)
RECEIVING CELLGENIC EXOSOMES
Cellgenic Flox Exosomes is a human tissue allograft that is received in a box on dry ice.
Before opening the box, check the label.
You must use graft before the expiry date or transfer to a freezer.
Move to a Freezer and store at -20C or lower.
Preparation and Dilution
The necessary materials for the procedure are:
Cellgenic Exosomes Vials
18 Gauge Needle
22 to 27 Gauge Needle
The Dilutant of choice
1% preservative free pain lidocaine
Platelet Rich Plasma
Glucose Solutions (eg.D5NS)
Lidocaine/marcaine with preservatives
Lidocaine/Marcaine in Joints
Chemical Debridement (eg. Santyl)
PREPARATION & MIXING
STEP BY STEP PROCEDURE
Removed the package from freezer. Cut the Package.
Defrost vial by holding still in hand for 3-5 minutes.(Do not shake the vial)
Fill syringe with dilutant. (Typically 1:1 ratio)
Draw Cellgenic Exosomes into syringe with 18G Needle.
Use a 22 to 27G needle for implantation.
POST IMPLANTATION PROTOCOL
Stimulation of inflammation of tissue is desired to increase success:
No Anti Inflammatories
Minimize Immobilization (joints)
Protected Active rehabilitation is recommended.
Global Stem Cells Group Inc 14750 NW 77TH Court
Suite 304, Miami Lakes, Florida, 33016, United States.