The combination of the mitochondrial-derived peptide MOTS-c with an AMP-activated protein kinase (AMPK) activator represents a novel and synergistic approach to modulating metabolism, improving mitochondrial function, and optimizing cellular resilience. Both compounds act on the AMPK-PGC-1α axis and offer complementary mechanisms that address metabolic dysfunction, inflammation, and aging.
Chronos MOTS-C 10 mg | AMPK Activator 25 mg
EXPANDED PROTOCOL
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA that acts as a retrograde signaling molecule from the mitochondria to the nucleus. It activates AMPK through its AICAR-mimetic function, improves insulin sensitivity and glucose uptake, promotes fatty acid oxidation, and reduces oxidative stress through Nrf2 activation.
Mechanism of Action of the AMPK Activator:
AMPK activators stimulate the AMPK pathway either by mimicking AMP or inhibiting mitochondrial complex I. Key actions include mitochondrial biogenesis through PGC-1α, induction of autophagy through ULK1 activation, metabolic reprogramming toward fatty acid oxidation, and anti-inflammatory effects through NF-κB inhibition.
The synergy is primarily based on their joint activation of the AMPK-PGC-1α axis through complementary mechanisms. This dual approach generates sustained AMPK activation, improved glucose homeostasis, more efficient fat metabolism, increased energy production, potent anti-inflammatory effects, and a slowing of biological aging.
Metabolic Optimization: improves insulin sensitivity, glucose uptake, and fatty acid oxidation.
Mitochondrial Support: stimulates biogenesis, increases energy production, and reduces mitochondrial deterioration.
Longevity and Anti-Aging: activates FOXO and SIRT signaling pathways and enhances autophagy and mitophagy.
Inflammation and Stress Resistance: reduces NF-κB activity and improves recovery following metabolic stress.
Weight Management: helps recover from metabolic syndrome and maintain healthy body composition.
Performance Optimization: provides exercise-like effects to extend healthy lifespan.
Lot-traced · COA on file · Sterility & mycoplasma tested
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CHRONOS: MOTS-c + AMPK Activator is an advanced research formulation combining a mitochondria-derived peptide with an AMPK activator for studies focused on cellular energy, mitochondrial function, metabolic signaling, and cellular adaptation.
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PRODUCT USAGE: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product is intended strictly for laboratory research and qualifies under appropriate regulatory frameworks for research-only use. It is not intended to diagnose, treat, cure, or prevent any disease or condition. This product should only be handled by licensed, qualified professionals. It is not intended for use by the general public. Bodily introduction of any kind into humans or animals is strictly forbidden by law.