1. Component Analysis
This protocol flips the script of the previous stack. Instead of relying on Semaglutide as the main driver, it makes MOTS-c the primary agent, with Semaglutide relegated to a “micro-dose” support role.
- MOTS-c (Mitochondrial ORF of the Twelve-Sixteen):
- Role: The “Metabolic Engine.”
- Mechanism: It acts directly on the mitochondria to increase glucose uptake and fatty acid oxidation (burning fat for fuel). It is often described as an “exercise mimetic” because it replicates the metabolic signaling of a workout.
- AOD-9604:
- Role: Targeted Fat Mobilization.
- Mechanism: Stimulates the breakdown of fat (lipolysis) and inhibits the formation of new fat (lipogenesis), specifically targeting adipose tissue without affecting blood sugar.
- Semaglutide (Micro-dose):
- Role: Background Insulin Support.
- Mechanism: At this low dose, it is likely intended to slightly improve insulin sensitivity and reduce “food noise” without causing the gastroparesis (slow stomach) or fatigue often associated with higher doses.
2. Protocol Breakdown
Core Bundle
- Target: The “Biohacker” or the “Skinny Fat” patient. Someone who wants to optimize cellular energy production and lean composition rather than just seeing the scale drop rapidly.
- The Logic: This is a “Cellular Energy” stack.
- MOTS-c upgrades the body’s hardware (mitochondria).
- AOD-9604 unlocks the fuel (fat stores).
- Semaglutide acts as a gentle regulator.
