1. Component Analysis
This protocol is specifically designed to avoid the “contraceptive” effect of traditional Testosterone Replacement Therapy (TRT). TRT signals the body to stop producing sperm; this protocol aims to stimulate the body’s natural machinery instead.
- Kisspeptin-10:
- Role: The “Gonadotropin Trigger.”
- Mechanism: It binds to receptors in the hypothalamus to stimulate the release of GnRH. This causes a downstream release of both LH (which boosts Testosterone) and FSH (which stimulates sperm production). It is the cornerstone of this stack because it maintains testicular size and function.
- DSIP (Delta Sleep-Inducing Peptide):
- Role: Sleep & Hormonal Support.
- Mechanism: Deep sleep is when the majority of endogenous Testosterone and Growth Hormone is produced. By optimizing Delta wave sleep, DSIP indirectly supports the hormonal profile. The claim of a “mild testosterone increase” is secondary to its stress-reducing (cortisol-lowering) effects, as high cortisol inhibits testosterone.
- CJC-1295 (No DAC) + Ipamorelin:
- Role: General Vitality.
- Mechanism: As noted in previous stacks, these improve body composition and recovery. In a fertility context, they are supportive rather than direct drivers of fertility.
- PT-141:
- Role: On-Demand Arousal.
- Mechanism: Acts centrally on the brain to induce erection and desire without affecting hormones or sperm count.
2. Protocol Breakdown
Core Bundle
- Target: Men in their reproductive prime (or later) who are actively trying to conceive or are fearful of testicular atrophy.
- The Logic: This is a “Upstream Stimulation” stack.
- Instead of giving the end product (Testosterone), it stimulates the source (Hypothalamus $\to$ Pituitary $\to$ Testes).
