What is Axis GHRP-2 Complex?
A comprehensive peptide formulation targeting multiple synergistic domains, creating a regenerative, anabolic, and autoimmune suppression stack for rheumatoid arthritis, tissue repair, and muscle regeneration.
Axis GHRP-2 1mg | Ipamorelin 2mg | PEG-MGF 100mcg | Thymalin 2mg | Tesamorelin 2mg
EXTENDED PROTOCOL
GHRP-2 (Growth Hormone Releasing Peptide-2):
Synthetic ghrelin mimetic binding to GHS-R1a receptor. Stimulates pulsatile GH release via hypothalamic and pituitary pathways, increases IGF-1 production promoting collagen synthesis, cartilage repair, and bone density.
Ipamorelin:
Selective GHS mimetic with minimal cortisol or prolactin stimulation. Binds GHS-R1a to trigger GH release without cortisol side effects, enhances bone turnover, cartilage preservation, and muscle mass.
PEG-MGF (Pegylated Mechano Growth Factor):
Splice variant of IGF-1 induced by injury; PEGylation increases half-life. Promotes myoblast proliferation and muscle repair, stimulates satellite cell activation in muscle and joint tissue.
Thymalin:
Thymus-derived peptide complex regulating immunity and cell differentiation. Balances T-helper subtypes (Th1/Th2/Th17/Treg), normalizes immune tolerance, reducing autoreactivity in RA.
Tesamorelin:
Stabilized GHRH analog resistant to DPP-4 degradation. Stimulates pituitary GH release via GHRH receptor, induces physiological GH profile, raising IGF-1 safely.
Clinical Applications:
- Rheumatoid Arthritis (RA) and Autoimmune Inflammation – Reduces IL-6, TNF-α, NF-κB, and CRP.
- Tissue & Cartilage Repair – Promotes chondrocyte proliferation and ECM restoration.
- Muscle Maintenance & Regeneration – Counters sarcopenia and chronic inflammation-induced muscle wasting.
- Systemic Inflammation Control – Reduces systemic inflammatory burden through multiple pathways.
- Body Composition Improvement – Reduces visceral fat and enhances lean muscle preservation.
Dosage & Administration:
30–90 IU per injection, administered once daily or every other day (EOD) via subcutaneous (SC) or intramuscular (IM) route.
Cycle Length:
Standard cycle is 4 weeks, then reassess symptoms before continuing. Cycles can be repeated as needed for chronic autoimmune or degenerative joint conditions.
Monitoring Parameters:
Inflammatory labs: CRP, ESR, IL-6, TNF-α. Hormonal axis: IGF-1, fasting insulin, testosterone. Musculoskeletal recovery markers: grip strength, muscle mass (DEXA).
Patients should be reassessed for inflammatory markers, joint pain, mobility, and muscle recovery before extending cycles.
Synergistic Mechanisms:
- GH Axis Stimulation – Triple-pulse GH surge → ↑ IGF-1, anabolic repair
- Tissue Repair – Joint, muscle, and synovial repair via satellite cell activation
- Immune Modulation – Reduces RA autoimmune misfiring via Treg restoration
- Anti-Inflammatory Signaling – Suppress NF-κB, IL-6, TNFα, CRP
- Muscle Regeneration – Boosts hypertrophy, counters wasting, enhances recovery