(Box of 5 Exosomes Vials + 5 Diluents)
This product is intended for use by medical professionals only. If you are an active licensed physician and wish to place an order please contact our team to create an account before placing an order.
YOUR ORDER WILL NOT BE SHIPPED WITHOUT PRIOR ACCOUNT ACTIVATION AND VERIFICATION.
20 mg of Lyophilized Exosome (5 billion exosomes/ml)
& 5 ml of Diluent
More Powerful. More Potent. Faster Results
Our clinically proven Paraben free and hypoallergenic intensive dual action Lyophilized Exosomes Orthopedics is designed to produce an Anti-Apoptotic, Anti-Fibrotic, Pro-Angiogenic, Pro-Differentiation, Pro-Proliferation, Immunomodulatory effect in the body. Delivering the concentrated power of 5 billion Lyophilized Exosomes, potent growth factors, peptides, coenzymes, minerals, amino acids, vitamins and irradiation reducing agents to stimulate tissue regeneration.
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Everything you have to know about our Lyophilized Exosomes Orthopedics
What are Exosomes?
Cellgenic Lyophilized Exosomes treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells.
These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.
In Vitro Testing
HUMAN FIBROBLAST CELL PROLIFERATION
Cellgenic Lyophilized Exosomes promotes skin cell proliferation by up to 80% in a dose-dependent manner. Cellgenic 3µg/ml 36.1% increase, Cellgenic 6µg/ml 84.0% increase, compared against positive control (1% GS).
ELASTIN INCREASE BY CELLGENIC
Cellgenic Lyophilized Exosomes may increase the elastin amount of human dermal fibroblasts up to 300# in vitro.
CELLULAR UPTAKE OF EXOSOMES
Human skin cells easily uptake Cellgenic Lyophilized Exosomes which means that stem cell-derived exosomes can message skin cells to “Do Something”.
COLLAGEN INCREASE BY CELLGENIC
After delivery of Cellgenic Lyophilized Exosomes into fibroblasts, neocollagenesis can increase up to 6 folds.
In Vivo Testing
Exosomes are nano-sized vesicles (30-200 nm) constrantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infultration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor (TNF-) in AD skin lesions of Nc/Nga ice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byoung Seung Cho, Jin Ock Kin, Dae Hyun Ha and Young Weon – Stem Cell Research Therapy)