What is Chronos MOTS-C Complex?
The combination of mitochondrial-derived peptide MOTS-c with an AMP-activated protein kinase (AMPK) activator represents a novel and synergistic approach to modulating metabolism, enhancing mitochondrial function, and optimizing cellular resilience. Both compounds converge on the AMPK-PGC-1α axis and offer complementary mechanisms that address metabolic dysfunction, inflammation, and aging.
Chronos MOTS-C 10mg | AMPK Activator 25mg
EXTENDED PROTOCOL
MOTS-c Mechanism of Action:
MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA, acting as a retrograde signaling molecule from the mitochondria to the nucleus. It provides AMPK activation via AICAR mimetic function, enhances insulin sensitivity and glucose uptake, promotes fatty acid oxidation, and reduces oxidative stress through Nrf2 activation.
AMPK Activator Mechanism of Action:
AMPK activators stimulate the AMPK pathway either by mimicking AMP or inhibiting mitochondrial complex I. Key actions include mitochondrial biogenesis via PGC-1α, induction of autophagy via ULK1 activation, metabolic reprogramming toward fatty acid oxidation, and anti-inflammatory effects via NF-κB inhibition.
Synergistic Integration:
The synergy is primarily based on their joint activation of the AMPK-PGC-1α axis through complementary mechanisms. This dual approach creates sustained AMPK activation, improved glucose homeostasis, enhanced fat metabolism, boosted energy output, robust anti-inflammatory effects, and slowed biological aging.
Clinical Applications:
- Metabolic Optimization – Enhances insulin sensitivity, glucose uptake, and fatty acid oxidation.
- Mitochondrial Support – Stimulates biogenesis, boosts energy output, reduces mitochondrial decay.
- Longevity & Anti-Senescence – Activates FOXO and SIRT signaling, enhances autophagy and mitophagy.
- Inflammation & Stress Resistance – Lowers NF-κB activity, improves recovery from metabolic stress.
- Weight Management – Supports metabolic syndrome recovery and healthy body composition.
- Performance Optimization – Provides exercise-mimetic effects to extend healthspan.
Dosage & Administration:
25–100 IU via subcutaneous (SC) or intramuscular (IM) route. Frequency: 3–7 times per week (daily or near-daily).
Cycle Length:
6–12 weeks for metabolic optimization and mitochondrial support. Best results observed with continuous use. Cycles can be repeated for ongoing support.
Reassessment:
After 30 days to adjust dosing and frequency based on individual response and metabolic markers.
Monitoring Parameters:
Glucose control markers (fasting glucose, HbA1c), mitochondrial performance indicators (VOâ‚‚ max, lactate threshold), and inflammation markers (CRP, IL-6).
Especially relevant for longevity medicine, metabolic syndrome, performance optimization, and immune modulation applications.
Synergistic Pathway Benefits:
- AMPK Activation – Indirect via AICAR-mimetic + Direct activation = Sustained AMPK activation
- Glucose Metabolism – GLUT4 upregulation + Insulin sensitivity = Improved glucose homeostasis
- Fat Oxidation – β-oxidation promotion + ACC inhibition = Enhanced fat metabolism
- Mitochondrial Health – Mitophagy enhancement + Biogenesis induction = Boosted energy output
- Inflammation Control – Nrf2 activation + NF-κB inhibition = Robust anti-inflammatory effect
- Longevity – Senescence reduction + Autophagy & mTOR inhibition = Slowed biological aging
