What is Eon LL-37 Complex?
A comprehensive antimicrobial and immune modulation formulation combining LL-37 cathelicidin with enhanced EGCG and Quercetin. This synergistic blend provides broad-spectrum pathogen clearance, immune rebalancing, mucosal barrier repair, and anti-senescence effects for chronic infections, autoimmune conditions, and post-viral recovery.
Eon LL-37 2mg | EGCG 250mg (Inclusion Complexed) | Quercetin 250mg (Inclusion Complexed)
EXTENDED PROTOCOL
LL-37:
Cationic antimicrobial peptide derived from cathelicidin (hCAP18). Disrupts bacterial, viral, and fungal membranes; effective against biofilms. Activates Toll-like receptors (TLR2, TLR9) and enhances chemotaxis of immune cells. Promotes angiogenesis and epithelial regeneration.
EGCG (Inclusion Complexed):
Polyphenol from green tea with enhanced bioavailability via cyclodextrin inclusion. Scavenges ROS and chelates metals; activates Nrf2. Suppresses NF-κB, IL-6, and TNF-α; reduces mast cell activation. Blocks viral entry and replication; interferes with bacterial quorum sensing.
Quercetin (Inclusion Complexed):
Flavonoid with enhanced absorption via cyclodextrin inclusion. Stabilizes mast cells, reducing histamine, prostaglandins, and leukotrienes. Inhibits NF-κB, COX-2, iNOS; acts as a zinc ionophore. Senolytic properties: clears senescent cells and suppresses SASP.
Synergistic Integration:
Multi-pathway pathogen kill, superior biofilm eradication, balanced immune response, mucosal resilience, chronic inflammation suppression, and tissue longevity through complementary mechanisms.
Strategic Applications:
- Post-viral recovery (EBV, COVID) – viral clearance, immune regulation, anti-fibrosis.
- MCAS / Histamine intolerance – mast cell stabilization and histamine burden reduction.
- Autoimmune support (Hashimoto’s, lupus) – Treg upregulation + NF-κB suppression + barrier healing.
- Gut/Lung Barrier Dysfunction – epithelial repair + inflammation control.
- Chronic Infections (Lyme, Candida, SIBO) – biofilm destruction + antimicrobial + cytokine modulation.
- Anti-aging & Inflammaging – senolytic + regenerative + anti-fibrotic effects.
Dosage & Administration:
25–100 IU via subcutaneous (SC), intramuscular (IM), or intravenous (IV) route. Frequency: 1–2 times per week.
Cycle Length:
2–4 weeks for antimicrobial effect or immune priming. Can be repeated depending on infection load or immune dysregulation status.
Clinical Applications:
Broad-spectrum antimicrobial action, immune priming & modulation, inflammation control & barrier protection, post-infection recovery, and anti-aging & inflammaging support.
Monitoring Parameters:
Inflammatory markers: CRP, IL-6, TNF-α. Immune profile: WBC differential, Treg/Th17 balance. Clinical outcomes: infection clearance, symptom regression, mucosal/gut health.
Especially valuable for patients with chronic infections, autoimmune conditions, and post-viral recovery needs.
Mechanistic Pathways:
- Antimicrobial – Multi-pathway pathogen disruption and biofilm eradication
- Biofilm Disruption – Superior matrix breakdown and adhesion inhibition
- Immune Modulation – TLR activation, Treg boost, mast cell stabilization
- Barrier Protection – Epithelial restoration, tight junction support, mucosal resilience
- Anti-Inflammatory – NF-κB suppression, Nrf2 activation, endotoxin neutralization
- Senescence/Aging – Tissue regeneration, fibrosis reduction, senolytic activity