A comprehensive antimicrobial and immune modulation formulation combining LL-37 cathelicidin with enhanced EGCG and Quercetin. This synergistic blend provides broad-spectrum pathogen clearance, immune rebalancing, mucosal barrier repair, and anti-senescence effects for chronic infections, autoimmune conditions, and post-viral recovery.
LL-37:
Cationic antimicrobial peptide derived from cathelicidin (hCAP18). Disrupts bacterial, viral, and fungal membranes; effective against biofilms. Activates Toll-like receptors (TLR2, TLR9) and enhances chemotaxis of immune cells. Promotes angiogenesis and epithelial regeneration.
EGCG (Inclusion Complexed):
Polyphenol from green tea with enhanced bioavailability via cyclodextrin inclusion. Scavenges ROS and chelates metals; activates Nrf2. Suppresses NF-κB, IL-6, and TNF-α; reduces mast cell activation. Blocks viral entry and replication; interferes with bacterial quorum sensing.
Quercetin (Inclusion Complexed):
Flavonoid with enhanced absorption via cyclodextrin inclusion. Stabilizes mast cells, reducing histamine, prostaglandins, and leukotrienes. Inhibits NF-κB, COX-2, iNOS; acts as a zinc ionophore. Senolytic properties: clears senescent cells and suppresses SASP.
Synergistic Integration:
Multi-pathway pathogen kill, superior biofilm eradication, balanced immune response, mucosal resilience, chronic inflammation suppression, and tissue longevity through complementary mechanisms.