CellGenic_logo
Provider Login
My Account
Become a Provider
CellGenic_logo

LL-37: Benefits, Handling, and Quality Standards

Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

What Is LL-37?

LL-37 is the only cathelicidin-family antimicrobial peptide produced in humans, cleaved from the hCAP-18 precursor protein and originally isolated from human neutrophils. It is studied in the research literature for broad-spectrum activity against gram-positive and gram-negative bacteria as well as *Candida albicans*, making it a compound of interest in antimicrobial-resistance and innate-immunity research.

Benefits and Uses

Available research on LL-37 spans several areas of interest, with the standard caveat that this is a basic-research compound and not a clinical therapeutic:
  • Antimicrobial mechanism research. LL-37 is studied for its ability to disrupt bacterial lipid bilayers in a concentration-dependent manner.
  • Innate immunity. LL-37/hCAP-18 has been shown to be constitutively expressed in human airway epithelia, not only in neutrophil granules, broadening its research relevance beyond infection response alone.
  • Structural biology. Structural studies show LL-37 can oligomerize and form channel-like assemblies under membrane-mimetic conditions, an active area of biophysical research.

How It Works

LL-37’s primary studied mechanism is direct disruption of the bacterial lipid bilayer once peptide concentration crosses a threshold, driven by its amphipathic helical structure. Beyond direct membrane disruption, LL-37 is described in the literature as having pleiotropic activity — meaning research interest extends beyond antimicrobial killing alone into broader innate-immune signaling roles.

Handling

LL-37 should be handled according to standard peptide storage and reconstitution practices, with a reconstitution reference tool available to convert a target concentration into a working solution volume.

Research teams can use the CellGenic reconstitution calculator as a reference when determining the appropriate volume for their established research concentration.

Quality and Verification Standards

Research use of LL-37 depends on independently verified identity and purity, given how sequence-sensitive antimicrobial-peptide research findings can be:

  • Certificate of Analysis (COA) confirming identity and purity per lot
  • HPLC purity data
  • Mycoplasma, sterility, and identity testing per lot
  • cGMP-aligned manufacturing documentation

Become a Provider

Full pricing, ordering, and batch-specific Certificates of Analysis are available exclusively to verified providers.

References:

  1. PubMed: LL-37 cathelicidin
  2. PubMed: LL-37 wound healing

FAQ

What is LL-37?
LL-37 is a human cathelicidin antimicrobial peptide derived from the hCAP-18 precursor protein. It is studied in research involving antimicrobial activity, innate immunity, and membrane interactions.
Research on LL-37 includes antimicrobial mechanisms, bacterial membrane disruption, innate-immune signaling, epithelial biology, and structural interactions with lipid membranes.
LL-37 is an amphipathic peptide that can interact with and disrupt bacterial lipid membranes. Research also examines its broader roles in innate immune signaling and cellular responses.
Yes. LL-37 is the only known human cathelicidin and has been studied for activity against various Gram-positive and Gram-negative bacteria as well as Candida albicans in experimental settings.
CellGenic LL-37 is supplied strictly as a research chemical for laboratory and in vitro experimentation. It is not marketed or supplied by CellGenic as a drug, medical treatment, food, or cosmetic.
Research-grade LL-37 should be supported by lot-specific documentation such as a Certificate of Analysis (COA), HPLC purity data, identity testing, sterility and mycoplasma testing where applicable, and relevant manufacturing documentation.
LL-37 should be handled according to the compound’s specification sheet and the laboratory’s established research protocols. Storage and reconstitution requirements can vary by formulation and experimental application.

REGULATORY DISCLAIMER · PEPTIDES

These products are intended for laboratory research use only. They are not drugs, foods, cosmetics, or medical treatments and must not be used for any form of human or animal administration. All information provided is for educational and scientific reference only and the products should be handled exclusively by licensed, qualified professionals. Misbranding, misuse, or mislabeling of these products as therapeutic or consumable substances is strictly prohibited by law.

CellGenic ships exclusively to Mexico, Argentina, Colombia, and Perú under local license. Verified-provider-only platform from CellGenic.

Shopping cart0
There are no products in the cart!
Continue shopping
Cart Gated

Cart is provider-gated. Log in to view.

Provider Login →